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Altogether, our facts supply evidence to the probable of mixing CX-5461 and PARPi for bettering the remedy of HR-deficient HGSOC. We display that CX-5461 boosts the synthetic lethal interaction of PARPi with HRD and clearly show that CX-5461 has a special mechanism of motion to PARPi. Importantly, we characterized BRCA-mutated and MYC targets gene
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